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Ενδιαφέρον περιστατικό μεταστατικού μελανώματος, στο κεντρικό site της Bristol Myers Squibb (BMS) με εγκεφαλικές μεταστάσεις θεραπευθέν χωρίς τη χρήση κλασσικών μεθόδων όπως η ακτινοβόληση εγκεφάλου
Written by Dr. Theofanis Floros, MD, Medical Oncologist Director, 5th Oncology Dept. Metropolitan General Hospital Assoc. Director, Athens Naval & Veterans Hospital Oncology Dept. Patient History • C.T., Male, Caucasian, aged 78 years • During a preventive annual thoracic CT for smoking habit, mediastinal lymphadenopathy and a Left Lower Lobe lesion consistent with metastasis was revealedRead more1975P – Next Generation Sequencing (NGS) for the identification of PARP inhibitors’ predictive biomarkers
T. Floros, E. Papadopoulou, V. Metaxa-Mariatou, A. TsantikidiZ, G. Kapetsis, C. Florou-Chatzigiannidou, A. Meintani, N. Touroutoglou, I. Boukovinas4, F. Stavridi, C. Papadimitriou, D. Ziogas, M. Theochari, E. Timotheadou, A. Fassas, Z. Saridaki-Zoras, M. Ozdogan, U. Demirci, G. Nasioulas INTRODUCTION The use of PARP inhibitors has been shown to be beneficial in tumors with BRCA1/2 mutations
Read moreΠρώτη χορήγηση TRASTUZUMAB DERUXTECAN (ENHERTU®) σε Έλληνες ασθενείς με γαστρεντερικό καρκίνο: Αποτελεσματικότητα και ασφάλεια
Μπαξεβάνος Π., Φλώρος Θ., 6ο Ελληνικό Συνέδριο Ογκολογίας Εισαγωγή To Enhertu® είναι ένα συζευγμένο φάρμακο τηςτραστουζουμάμπης (μονοκλωνικό αντίσωμα έναντι του υποδοχέα HER2) με 8 μόρια δερουξτεκάνης (αναστολέας τοποίσο με ράσ η ς I). Έχει λάβει ένδειξη από ΕΜΑ για τη θεραπεία ασθενών με ανεγχείρητο ΗΕ82-θετικό καρκίνο μαστού, και πρόοδο νόσου σε 2 τουλάχιστον στοχευτικές αντι-ΗΕΚ2
Read moreRevisiting the Implications of Positive Germline Testing Results Using Multi-gene Panels in Breast Cancer Patients
GEORGIOS N. TSAOUSIS, EIRINI PAPADOPOULOU, KONSTANTINOS AGIANNITOPOULOS, GEORGIA PEPE, NIKOLAOS TSOULOS, IOANNIS BOUKOVINAS, THEOFANIS FLOROS, RODONIKI IOSIFIDOU, OURANIA KATOPODI, ANNA KOUMARIANOU, CHRISTOS MARKOPOULOS, KONSTANTINOS PAPAZISIS, VASILEIOS VENIZELOS, ACHILLEAS KAPSIMALIS, GRIGORIOS XEPAPADAKIS, AMANDA PSYRRI, EUGENIU BANU, DAN TUDOR ENIU, ALEXANDRU BLIDARU, DANA LUCIA STANCULEANU, ANDREI UNGUREANU, VAHIT OZMEN, SUALP TANSAN, MEHMET TEKINEL, SUAYIB YALCIN and GEORGE
Read moreAnalysis of hereditary cancer syndromes by using a panel of genes: Novel and multiple pathogenic mutations
Tsoulos N, Tsaousis GN, Papadopoulou E, Agiannitopoulos K, Pepe G, Kambouri S, Apessos A, Diamantopoulos N, Floros T, Iosifidou R, Katopodi O, Koumarianou A, Markopoulos C, Papazisis K, Venizelos V, Xanthakis I, Xepapadakis G, Banu E, Eniu DT, Negru S, Stanculeanu DL, Ungureanu A, Ozmen V, Tansan S, Tekinel M, Yalcin S, Nasioulas G. Analysis
Read moreTumor molecular profiling of NSCLC patients using next generation sequencing
Nikolaos Tsoulos, Eirini Papadopoulou, Vasiliki Metaxa-Mariatou, Georgios Tsaousis, Chrisoula Efstathiadou, Georgia Tounta, Aikaterini Scapeti, Eugenia Bourkoula, Pavlos Zarogoulidis, George Pentheroudakis, Stylianos Kakolyris, Ioannis Boukovinas, Pavlos Papakotoulas, Elias Athanasiadis, Theofanis Floros, Anna Koumarianou, Vasileios Barbounis, Anca Dinischiotu, George Nasioulas, “Tumor molecular profiling of NSCLC patients using next generation sequencing”, Oncology Rep. 2017 Dec; 38(6):3419-3429. https://doi.org/10.3892/or.2017.6051 Abstract
Read moreA unique gene expression signature is significantly differentially expressed in tumor-positive or tumor-negative sentinel lymph nodes in patients with melanoma
A. Tarhini, Ahmad & Floros, Theofanis & Lin, Hui-Min & Lin, Yan & Rahman, Zahra & Ashraf, Madeeha & Vallabhaneni, Priyanka & Sander, Cindy & N.M. Rao, Uma & Panelli, Monica & LaFramboise, William & Kirkwood, John. August 2017, DOI: 10.1097/CMR.0000000000000383 Abstract The purpose of this study was to learn whether molecular characterization through gene expression
Read morePhase 1/2 study of rilotumumab (AMG 102), a hepatocyte growth factor inhibitor, and erlotinib in patients with advanced non–small cell lung cancer
Ahmad A. Tarhini MD, PhD, Imran Rafique MDDS, Theofanis Floros MD, Phu Tran MD, William E. Gooding MS, Liza C. Villaruz MD, Timothy F. Burns MD, PhD, David M. Friedland MD, Daniel P. Petro MD, Mariya Farooqui PhD, Jose Gomez-Garcia PhD, Autumn Gaither-Davis BS, MPH, Sanja Dacic MD, PhD, Athanassios Argiris MD, Mark A Socinski MD, Laura P. Stabile PhD, Jill M. Siegfried PhD First published: 4 May
Read moreMultidisciplinary Management of Gastrointestinal Cancers
ISBN: 978-981-4651-87-5 This invaluable book provides an introduction to the development and application of molecular biology with a focus on translational research development in a variety of gastrointestinal cancers. Multidisciplinary Management of Gastrointestinal Cancers will emphasize the multidisciplinary aspects of GI cancer diagnosis, treatment and management, introduce the application of new techniques in GI cancer
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